Where are agranulocytes primarily produced in the human body?

Agranulocytes, which include lymphocytes and monocytes, are primarily produced in the red bone marrow. In adults, red bone marrow is the site of hematopoiesis, where all blood cells, including agranulocytes, are generated from hematopoietic stem cells. While lymphocytes undergo further maturation in other organs, such as the thymus for T cells and peripheral tissues for B cells, their initial production occurs in the bone marrow. This makes the red bone marrow the primary site for the generation of agranulocytes, ensuring that these important components of the immune system are readily available to respond to infections and other challenges.

The liver and spleen play roles in filtering blood and recycling components of aged or damaged blood cells, but they are not the primary sites of agranulocyte production. The thymus, while crucial for T cell maturation, does not produce the cells; rather, it is the red bone marrow where the precursor cells originate.