What disease is characterized by hyperthyroid issues and often includes protruding eyes?

Grave's disease is an autoimmune disorder that leads to hyperthyroidism, which is an overproduction of thyroid hormones. This condition often results in various symptoms, one of the most recognizable being exophthalmos, or protruding eyes. This occurs due to an inflammatory response in the tissues behind the eyes, leading to swelling and pushing the eyeballs forward.

Grave's disease is characterized not only by hyperthyroid symptoms, such as increased metabolism, weight loss, and heat intolerance, but also by its distinctive ocular manifestations. Understanding these associations is important in clinical settings for diagnosis. Meanwhile, the other conditions listed—such as Hashimoto's disease, which causes hypothyroidism, Cushing's syndrome, characterized by excess cortisol, and diabetes mellitus, primarily related to insulin and glucose metabolism—do not present with both hyperthyroid symptoms and protruding eyes. Thus, Grave's disease is the clear choice for this question.